Art Wynwood emerged as a significant cultural event in Miami's vibrant art scene, adding to the city's reputation as a global hub for contemporary art. The fair debuted in 2012, coinciding with Presidents Day weekend, and quickly gained recognition as a premier destination for collectors, artists, and enthusiasts alike.

The inception of Art Wynwood was a response to the growing demand for a dedicated platform showcasing contemporary and modern art during Miami's renowned Art Week. With its strategic timing and location in the heart of Wynwood, a neighborhood known for its colorful murals and galleries, the fair tapped into the burgeoning interest in art and culture in the city.